Mystical experiences transcend the subject-object dichotomy of ordinary experiences to reveal a fundamental level of nondual awareness as the ground of thinking. Neuroscience provides an objective window to understand the character of nondual experiences and how they transform mind/body functioning over time. This talk will explore nondual experiences occurring during meditation practices, with emphasis on the experience of pure consciousness, content-free self-awareness, described during Transcendental Meditation practice.